I am looking over my flight options to Tucson today. I don't have much in the way of options, so it's easy to narrow down the possibilities.
Option #1, I fly AC from here to Phoenix (10h), then it's a 1.5h drive to Tucson
Option #2, I fly Delta out of F'ton to Tucson (11h)
#1 is cheaper and we'll have to rent a car anyway. #2 is more expensive but will eliminate driving for an hour and a half after having flown for 10h. Both have me leaving at the crack of dawn and returning late, though #1 has a bit better times - except for that whole getting to Phoenix and flying out at 9:30am (1.5h drive, plus arrive 2h before flight, so 6am-ish leaving Tucson, as opposed to 4am for #2 to make a 6am flight). I could always stay my last night in Phoenix near the airport as well.